pancreatic cancer, agents that cure this highly resis-tant and metastasizing disease are not available. Con-siderable attention has focused on broccoli compound sulforaphane (SF), which is suggested as combination therapy for targeting of pancreatic cancer stem cells (CSCs). However, there are concerns that antioxidative

How the epigenetic benefits of eating broccoli sprouts overcame my genetics and saved my life from cancer, heart disease and Alzheimer's. We urge you to view

Nonobese diabetic/severe combined im-munodeficient mouse model exhibited that sulfora-phane eliminated breast cancer stem cells in vivo. Li et al. OF2 Clin Cancer Res; 16(9) May 1 Cancer Therapy: Preclinical Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells Yanyan Li1,3, Tao Zhang1, Hasan Korkaya2, Suling Liu2, Hsiu-Fang Lee1, Bryan Newman1, Yanke Yu1, The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforaphane targeted and killed the cancer stem cells and prevented Sulforaphane. Sulforaphane is an organic isothiocyanate (ITC) found in cruciferous plants such as broccoli, and within the diabetic setting, sulforaphane has been shown to (a) protect β-cell damage by suppressing NFκB pathways [337], and (b) in studies of islet transplantation, pre-treatment with sulforaphane 24 hours prior to transplantation was found to lead to improved long-term islet Cancer stem cells (CSCs) constitute a subpopulation of tumor cells that possess self-renewal and tumor initiation capacity, and the ability to give rise to the heterogeneous lineages of cancer 2010-04-09 · Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention.

Sulforaphane cancer stem cells

Int J Oncol. 2014 May;44 (5):1470-80. doi: 10.3892/ijo.2014.2335. Epub 2014 Mar 10. Herr I., Rausch V. (2012) Sulforaphane as New Therapeutic Agent for Targeting of Cancer Stem Cells with Focus to Prostate and Pancreatic Cancer.

…. Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism.

2012-11-06

Epub 2014 Mar 10. 2010-05-01 Herr I., Rausch V. (2012) Sulforaphane as New Therapeutic Agent for Targeting of Cancer Stem Cells with Focus to Prostate and Pancreatic Cancer. In: Hayat M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Stem Cells and Cancer Stem Cells, vol 7.

We herein report that sulforaphane (SFN), a potent anti-cancer and well-tolerated dietary compound, inhibits cancer stem-like cell (CSC) properties and enhances therapeutic efficacy of cisplatin in human non-small cell lung cancer (NSCLC). SFN exerted these functions through upregulation of miR-214, which in turn targets the coding region of c-MYC.

Sulforaphane eliminates breast CSCs in vivo In this study, we hypothesized that sulforaphane, a dietary component abundant in broccoli and its sprouts, can inhibit malignant cell proliferation and tumor sphere formation of cancer stem-like cells (CSC) in TNBC. CSC population was isolated using FACS analysis with the combined stem cell surface markers, CD44+/CD24−/CD49f+.

doi: 10.3892/ijo.2014.2335. Epub 2014 Mar 10.
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Both arti Squamous cell cancer is a type of skin cancer.

2010-05-01 2012-03-13 Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate Georgios Kallifatidis , Sabrina Labsch, Vanessa Rausch, Juergen Mattern, Jury Gladkich, Gerhard Moldenhauer, Markus W. Büchler, Alexei V. Salnikov, Ingrid Herr Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr. 2004;134(9):2229-36 28. Li Y, Zhang T, Korkaya H. et al.
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Sulforaphane eradicates pancreatic cancer stem cells by NF-κB Emerging evidence suggests that cancer stem cells (CSCs) play a central role in the pathogenesis of cancer. We identified CSCs in pancreatic cancer cell lines and patient tumors by expression of CSC markers and correlation to growth on nude mice, differentiation

OF2 Clin Cancer Res; 16(9) May 1 Cancer Therapy: Preclinical Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells Yanyan Li1,3, Tao Zhang1, Hasan Korkaya2, Suling Liu2, Hsiu-Fang Lee1, Bryan Newman1, Yanke Yu1, The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforaphane targeted and killed the cancer stem cells and prevented Sulforaphane. Sulforaphane is an organic isothiocyanate (ITC) found in cruciferous plants such as broccoli, and within the diabetic setting, sulforaphane has been shown to (a) protect β-cell damage by suppressing NFκB pathways [337], and (b) in studies of islet transplantation, pre-treatment with sulforaphane 24 hours prior to transplantation was found to lead to improved long-term islet Cancer stem cells (CSCs) constitute a subpopulation of tumor cells that possess self-renewal and tumor initiation capacity, and the ability to give rise to the heterogeneous lineages of cancer 2010-04-09 · Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism.

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synthetic racemic analogue of broccoli constituent l-sulforaphane inhibitory effect of BITC on self-renewal of breast cancer stem cells. (S.V.Singh, unpublished

According to a Canadian study, eating cauliflower or broccoli can reduce the spread of a tumor by 50 percent. Also, researcher Elizabeth Jeffery of the University of Illinois spent four years working on studies of sulforaphane. An interesting observation is that sulforaphane was able to inhibit stem/progenitor cells at the concentrations (0.5~ 5 μM) that hardly affected the bulk population of cancer cells, implying that sulforaphane is likely to preferentially target stem/progenitor cells compared to the differentiated cancer cells.